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Advancing patient care with
meaningful evidence.

The Proof Is In The Patient

We are committed to developing best-in-class evidence to improve treatment and support patient access. Our evidence portfolio advances the use of spinal cord stimulation for pain areas commonly treated with SCS and expands patient access to new & industry exclusive indications such as pain from diabetic neuropathy.

Landmark Publications

Nevro aims to develop and publish rigorous evidence to support critical decisions made by physicians, regulators and payors.

Highlighted Evidence

Chronic Low Back Pain and Leg Pain

Author Source Title Download File
Stauss T., et al. Annals of Clinical and Translational Neurology 2019 A Multicenter Real‐world Review Of 10 kHz Scs Outcomes For Treatment Of Chronic Trunk And/or Limb Pain Link
Amirdelfan K., et al. Quality of Life Research 2018 Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The Senza-rct Link
DiBenedetto D.J., et al. Journal of Pain Research 2018 10 kHz Spinal Cord Stimulation: A Retrospective Analysis Of Real-world Data From A Community-based, Interdisciplinary Pain Facility Link
Kapural L., et al. Neurosurgery 2016 Comparison Of 10 kHz High-frequency And Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: 24-month Results From A Multicenter, Randomized, Controlled Pivotal Trial. Link
Al-Kaisy A., et al. Neuromodulation 2015 The Use Of 10-kilohertz Spinal Cord Stimulation In A Cohort Of Patients With Chronic Neuropathic Limb Pain Refractory To Medical Management. Link
Kapural L., et al. Anesthesiology 2015 Novel 10 kHz High-frequency Therapy (hf10 Therapy) Is Superior To Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: The Senza-rct Randomized Controlled Trial. Link
Al-Kaisy A., et al. Pain Medicine 2014 Sustained Effectiveness Of 10 kHz High-frequency Spinal Cord Stimulation For Patients With Chronic, Low Back Pain: 24-month Results Of A Prospective Multicenter Study. PDF
Tiede J., et al. Neuromodulation 2013 Novel Spinal Cord Stimulation Parameters In Patients With Predominant Back Pain. Link
Van Buyten J.P., et al. Neuromodulation 2013 High-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back Pain Patients: Results Of A Prospective Multicenter European Clinical Study. Link

Upper Limb Pain

Author Source Title Download File
Amirdelfan K., et al. Neurosurgery 2019 High-frequency Spinal Cord Stimulation At 10 kHz In The Treatment Of Combined Neck And Arm Pain: Results From A Prospective Multicenter Study. PDF
El Majdoub F., et al. Annals of Clinical and Translational Neurology 2019 10 kHz Cervical Scs For Chronic Neck And Upper Limb Pain: 12 Months' Results. PDF

Non-Surgical Refractory Back Pain

Author Source Title Download File
Al-Kaisy A., et al. Anaesthesia 2020 10 kHz spinal cord stimulation for the treatment of non‐surgical refractory back pain: subanalysis of pooled data from two prospective studies PDF
Patel N. NANS 2019 Taking Spinal Cord Stimulation Beyond Failed Back Surgery Syndrome: Design Of A Multicenter Rct. PDF
Al-Kaisy A., et al. Neuromodulation 2017 10 kHz High-frequency Spinal Cord Stimulation For Chronic Axial Low Back Pain In Patients With No History Of Spinal Surgery: A Preliminary, Prospective, Open Label, And Proof Of Concept Study. Link
Al-Kaisy A., et al. Pain Medicine 2017 Long-term Improvements In Chronic Axial Low Back Pain Patients Without Previous Spinal Surgery: A Cohort Analysis Of 10 kHz High-frequency Spinal Cord Stimulation Over 36 Months. PDF
Ahmadi S.A., et al. Neuromodulation 2017 High-frequency Spinal Cord Stimulation In Surgery-naïve Patients-a Prospective Single-center Study. Link

Opioid Reduction and Quality of Life

Author Source Title Download File
Al-Kaisy A., et al. Annals of New York Academy of Sciences 2019 Opioid‐sparing Effects Of 10 kHz Spinal Cord Stimulation: A Review Of Clinical Evidence PDF
Al-Kaisy A., et al. Scientific Reports 2019 10 kHz Scs Therapy For Chronic Pain, Effects On Opioid Usage: Post Hoc Analysis Of Data From Two Prospective Studies PDF
Amirdelfan K., et al. Quality of Life Research 2018 Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The Senza-rct PDF
DiBenedetto D.J., et al. Journal of Pain Research 2018 10 k\Hz Spinal Cord Stimulation: A Retrospective Analysis Of Real-world Data From A Community-based, Interdisciplinary Pain Facility PDF

Additional Resources

Author Source Title Download File
Sayed D., et al. Journal of Pain Research 2020 Retrospective Analysis of Real-World Outcomes of 10 kHz SCS in Patients with Upper Limb and Neck Pain PDF
Kapural L., et al. Clinical and Translational Gastroenterology 2020 Treatment of Chronic Abdominal Pain With 10-kHz Spinal Cord Stimulation: Results From a 12-Month Prospective, Multicenter, Feasibility Study PDF
Sayed D., et al. CNS Neuroscience & Therapeutics 2020 Pain Relief and Improvement in Quality of Life with 10 kHz SCS Therapy: Summary of Clinical Evidence* PDF
Lee K.Y., et al. Neuroscience 2020 Low-intensity, Kilohertz Frequency Spinal Cord Stimulation Differently Affects Excitatory and Inhibitory Neurons in the Rodent Superficial Dorsal Horn PDF
Rosenberg W. S., et al. NANS 2020 Salvage of Previously Failed Spinal Cord Stimulation Using 10 kHz SCS Through a ‘Pocket Trial’ Technique PDF
Russo M., et al. NANS 2020 Improved Versatility and Frequency Pairing Capabilities with 10 kHz Spinal Cord Stimulation for the Treatment of Chronic Pain PDF
Gill, J.S., et al. Pain Practice 2019 High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Complex Regional Pain Syndrome: A Case Series of Patients with or Without Previous Spinal Cord Stimulator Implantation PDF
Al-Kaisy A., et al. Annals of New York Academy of Sciences 2019 Opioid‐Sparing Effects of 10 kHz Spinal Cord Stimulation: A Review of Clinical Evidence PDF
Manfield, J., et al. Stereotactic and Functional Neurosurgery 2019 Safety and Utility of Spinal Magnetic Resonance Imaging in Patients with High-Frequency Spinal Cord Stimulators: A Prospective Single-Centre Study PDF
Palmisani S., et al. NANS 2019 Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation (SCS) for the Management of Refractory Chronic Migraine*: A Prospective Study PDF
Galan V., et al. ASRA 2018 A Prospective Clinical Trial to Assess High Frequency Spinal Cord Stimulation (HF-SCS) at 10 kHz in the Treatment of Chronic Intractable Pain from Peripheral Polyneuropathy (PPN) PDF
Tate J., et al. NANS 2019 A Prospective, Multi-Site, Clinical Trial of the Senza™ Spinal Cord Stimulation (SCS) System in the Treatment of Chronic Pelvic Pain. PDF
Gupta M., et al. ASRA 2018 Spinal Cord Stimulation at 10 kHz for the Treatment of Chronic Focal Neuropathic Post-Surgical Pain. PDF
Billet B., et al. NANS 2019 High Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Focal, Chronic, Post-Surgical Neuropathic Pain. PDF
Groote S.D., et al. Neuromodulation 2018 Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional Magnetic Resonance Imaging Study. PDF
Lambru G., et al. The Journal of Headache and Pain 2016 Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation in Chronic Refractory Primary Headaches: a Retrospective Case Series* PDF
Arcioni R., et al. European Journal of Pain Cervical 10 kHz Spinal Cord Stimulation in The Management Of Chronic, Medically Refractory Migraine: A Prospective, Open-Label, Exploratory Study* PDF

*Indication is off-label for SCS in the EU IFU. For on-label uses, see Safety Information