Advancing patient care with meaningful evidence.

The Proof Is In The Patient

We are committed to developing best-in-class evidence to improve treatment and support patient access. Our evidence portfolio advances the use of spinal cord stimulation for pain areas commonly treated with SCS and expands patient access to new & industry exclusive indications such as pain from diabetic neuropathy.

Landmark Publications

Nevro aims to develop and publish rigorous evidence to support critical decisions made by physicians, regulators and payors.

ARGOFF 2024

Improvement in Protective Sensation: Clinical Evidence From a Randomized Controlled Trial for Treatment of Painful Diabetic Neuropathy With 10 kHz Spinal Cord Stimuation

Download

PATEL 2023

Durable response at 24 months with high-frequency spinal cord stimulation for nonsurgical refractory back pain

Download

PETERSEN 2023

Long-term efficacy of high-frequency (10 kHz) spinal cord stimulation for the treatment of painful diabetic neuropathy: 24-Month results of a randomized controlled trial

Download

THE SENZA-RCT

The first multicenter, prospective, randomized, controlled pivotal study of an SCS system

Download

SENZA-PDN

The largest RCT studying PDN

Download

SENZA-PDN 12 MONTH

12-Month durability and crossover results published in Diabetes Care

Download

NSRBP RCT

12-Month NSRBP RCT results published in the Journal of Neurosurgery: Spine

Download

Highlighted Evidence

Chronic Low Back Pain and Leg Pain

Stauss T., et al.

Annals of Clinical and Translational Neurology 2019

A Multicenter Real‐world Review Of 10 kHz SCS Outcomes For Treatment Of Chronic Trunk And/or Limb Pain

Amirdelfan K., et al.

Quality of Life Research 2018

Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The SENZA-RCT

DiBenedetto D.J., et al.

Journal of Pain Research 2018

10 kHz Spinal Cord Stimulation: A Retrospective Analysis Of Real-World Data From A Community-Based, Interdisciplinary Pain Facility

Kapural L., et al.

Neurosurgery 2016

Comparison Of 10 kHz High-frequency And Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: 24-month Results From A Multicenter, Randomized, Controlled Pivotal Trial.

Al-Kaisy A., et al.

Neuromodulation 2015

The Use Of 10-kilohertz Spinal Cord Stimulation In A Cohort Of Patients With Chronic Neuropathic Limb Pain Refractory To Medical Management.

Kapural L., et al.

Anesthesiology 2015

Novel 10 kHz High-frequency Therapy (hf10 Therapy) Is Superior To Traditional Low-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back And Leg Pain: The SENZA-RCT Randomized Controlled Trial.

Al-Kaisy A., et al.

Pain Medicine 2014

Sustained Effectiveness Of 10 kHz High-frequency Spinal Cord Stimulation For Patients With Chronic, Low Back Pain: 24-month Results Of A Prospective Multicenter Study.

Tiede J., et al.

Neuromodulation 2013

Novel Spinal Cord Stimulation Parameters In Patients With Predominant Back Pain.

Van Buyten J.P., et al.

Neuromodulation 2013

High-frequency Spinal Cord Stimulation For The Treatment Of Chronic Back Pain Patients: Results Of A Prospective Multicenter European Clinical Study.

Upper Limb Pain

Amirdelfan K., et al.

Neurosurgery 2019

High-frequency Spinal Cord Stimulation At 10 kHz In The Treatment Of Combined Neck** And Arm Pain: Results From A Prospective Multicenter Study.

El Majdoub F., et al.

Annals of Clinical and Translational Neurology 2019

10 kHz Cervical SCS For Chronic Neck** And Upper Limb Pain: 12 Months' Results.

Non-Surgical Refractory Back Pain

Kapural L., et al.

Pain Physician Journal 2024

Demographics and PainDETECT as Predictors of 24-Month Outcomes for 10 kHz SCS in Nonsurgical Refractory Back Pain.

Al-Kaisy A., et al.

Anaesthesia 2020

10 kHz spinal cord stimulation for the treatment of non‐surgical refractory back pain: subanalysis of pooled data from two prospective studies

Patel N.

NANS 2019

Taking Spinal Cord Stimulation Beyond Failed Back Surgery Syndrome: Design Of A Multicenter RCT.

Al-Kaisy A., et al.

Neuromodulation 2017

10 kHz High-frequency Spinal Cord Stimulation For Chronic Axial Low Back Pain In Patients With No History Of Spinal Surgery: A Preliminary, Prospective, Open Label, And Proof Of Concept Study.

Al-Kaisy A., et al.

Pain Medicine 2017

Long-term Improvements In Chronic Axial Low Back Pain Patients Without Previous Spinal Surgery: A Cohort Analysis Of 10 kHz High-frequency Spinal Cord Stimulation Over 36 Months.

Ahmadi S.A., et al.

Neuromodulation 2017

High-frequency Spinal Cord Stimulation In Surgery-naïve Patients-a Prospective Single-center Study.

Opioid Reduction and Quality of Life

Al-Kaisy A., et al.

Annals of New York Academy of Sciences 2019

Opioid‐Sparing Effects of 10 kHz Spinal Cord Stimulation: A Review of Clinical Evidence

Al-Kaisy A., et al.

Scientific Reports 2019

10 kHz SCS Therapy For Chronic Pain, Effects On Opioid Usage: Post Hoc Analysis Of Data From Two Prospective Studies

Amirdelfan K., et al.

Quality of Life Research 2018

Long-term Quality Of Life Improvement For Chronic Intractable Back And Leg Pain Patients Using Spinal Cord Stimulation: 12-month Results From The SENZA-RCT

DiBenedetto D.J., et al.

Journal of Pain Research 2018

10 kHz Spinal Cord Stimulation: A Retrospective Analysis Of Real-World Data From A Community-Based, Interdisciplinary Pain Facility

Additional Resources

Taylor R., et al.

Journal of Managed Care & Specialty Pharmacy 2023

Health care resource utilization and costs in patients with painful diabetic neuropathy treated with 10 kHz spinal cord stimulation therapy

Sayed D., et al.

Journal of Pain Research 2020

Retrospective Analysis of Real-World Outcomes of 10 kHz SCS in Patients with Upper Limb and Neck Pain**

Kapural L., et al.

Clinical and Translational Gastroenterology 2020

Treatment of Chronic Abdominal Pain** With 10-kHz Spinal Cord Stimulation: Results From a 12-Month Prospective, Multicenter, Feasibility Study

Sayed D., et al.

CNS Neuroscience & Therapeutics 2020

Pain Relief and Improvement in Quality of Life with 10 kHz SCS Therapy: Summary of Clinical Evidence**

Lee K.Y., et al.

Neuroscience 2020

Low-intensity, Kilohertz Frequency Spinal Cord Stimulation Differently Affects Excitatory and Inhibitory Neurons in the Rodent Superficial Dorsal Horn

Rosenberg W. S., et al.

NANS 2020

Salvage of Previously Failed Spinal Cord Stimulation Using 10 kHz SCS Through a ‘Pocket Trial’ Technique

Russo M., et al.

NANS 2020

Improved Versatility and Frequency Pairing Capabilities with 10 kHz Spinal Cord Stimulation for the Treatment of Chronic Pain

Gill, J.S., et al.

Pain Practice 2019

High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Complex Regional Pain Syndrome: A Case Series of Patients with or Without Previous Spinal Cord Stimulator Implantation

Al-Kaisy A., et al.

Annals of New York Academy of Sciences 2019

Opioid‐Sparing Effects of 10 kHz Spinal Cord Stimulation: A Review of Clinical Evidence

Manfield, J., et al.

Stereotactic and Functional Neurosurgery 2019

Safety and Utility of Spinal Magnetic Resonance Imaging in Patients with High-Frequency Spinal Cord Stimulators: A Prospective Single-Centre Study

Palmisani S., et al.

NANS 2019

Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation (SCS) for the Management of Refractory Chronic Migraine**: A Prospective Study

Galan V., et al.

ASRA 2018

A Prospective Clinical Trial to Assess High Frequency Spinal Cord Stimulation (HF-SCS) at 10 kHz in the Treatment of Chronic Intractable Pain from Peripheral Polyneuropathy (PPN)

Tate J., et al.

NANS 2019

A Prospective, Multi-Site, Clinical Trial of the Senza™ Spinal Cord Stimulation (SCS) System in the Treatment of Chronic Pelvic Pain.

Gupta M., et al.

ASRA 2018

Spinal Cord Stimulation at 10 kHz for the Treatment of Chronic Focal Neuropathic Post-Surgical Pain.

Billet B., et al.

NANS 2019

High Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Focal, Chronic, Post-Surgical Neuropathic Pain.

Groote S.D., et al.

Neuromodulation 2018

Magnetic Resonance Imaging Exploration of the Human Brain During 10 kHz Spinal Cord Stimulation for Failed Back Surgery Syndrome: A Resting State Functional Magnetic Resonance Imaging Study.

Lambru G., et al.

The Journal of Headache and Pain 2016

Safety and Efficacy of Cervical 10 kHz Spinal Cord Stimulation in Chronic Refractory Primary Headaches: a Retrospective Case Series**

Arcioni R., et al.

European Journal of Pain

Cervical 10 kHz Spinal Cord Stimulation in The Management Of Chronic, Medically Refractory Migraine: A Prospective, Open-Label, Exploratory Study**

*

Pending FDA approval
**

Publication contains unapproved use(s) of SCS in the US which have not been reviewed by the FDA for safety and efficacy. For on-label uses, see Safety Information.